Genetics of Frontotemporal Lobar Degeneration

This session track delves into the genetic underpinnings of Frontotemporal Lobar Degeneration (FTLD), a group of disorders characterized by progressive damage to the frontal and temporal lobes of the brain. It explores the key genetic mutations associated with FTLD, including those in the MAPT, GRN, and C9orf72 genes, which are linked to tauopathies, tau-negative frontotemporal dementia, and motor neuron disease, respectively. The track will cover how these genetic factors influence disease onset, progression, and clinical presentation. Discussions will include advances in genetic testing and their role in diagnosis and personalized treatment strategies. Additionally, the session will address ongoing research into gene-environment interactions and potential therapeutic targets. Attendees will gain a comprehensive understanding of the genetic basis of FTLD, its impact on disease mechanisms, and implications for future research and clinical practice.

 

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