6^th Annual Dementia Congress

Genetics, Genomics & Next-Generation Research

Genetic and genomic research has become a cornerstone in understanding the risk factors, progression, and potential therapeutic targets for dementia. This topic will explore the latest discoveries in familial and sporadic forms of dementia, including mutations in genes such as APP, PSEN1, PSEN2, and APOE, and their implications for disease onset and severity. Advances in genome-wide association studies (GWAS) and next-generation sequencing technologies are uncovering novel genetic variants and pathways that contribute to neurodegeneration. The role of epigenetics, gene-environment interactions, and regulatory mechanisms in influencing disease susceptibility and progression will also be discussed. Participants will gain insights into how these discoveries are being translated into personalized medicine approaches, enabling tailored prevention and treatment strategies for at-risk individuals. Cutting-edge research on polygenic risk scores, functional genomics, and CRISPR-based interventions will be highlighted as potential tools to modify disease trajectory. Emphasis will be placed on collaborative efforts between geneticists, neurologists, and clinical researchers to bridge the gap between laboratory findings and practical applications. This topic encourages discussion on ethical considerations surrounding genetic testing, data privacy, and implications for families and caregivers. By understanding the molecular underpinnings of dementia through genetic and genomic perspectives, participants will be equipped to integrate these insights into research, clinical practice, and the development of next-generation therapies that target the root causes of neurodegeneration.