Neurodegeneration & Aging

Aging is the greatest risk factor for dementia, and understanding the mechanisms of neurodegeneration in aging brains is critical for prevention and treatment. This topic will explore cellular and molecular processes that occur during normal aging and how they intersect with pathological changes in dementia, including protein aggregation, oxidative stress, mitochondrial dysfunction, and neuroinflammation. Participants will examine the impact of vascular factors, metabolic changes, and lifestyle influences on cognitive decline, highlighting the interplay between systemic health and brain function. Recent research on neuroplasticity, synaptic resilience, and neuroprotective strategies will be discussed, providing insights into potential interventions to slow or prevent neurodegeneration. Emphasis will be placed on translational approaches, including how animal and cellular models of aging inform clinical strategies, and the development of biomarkers to distinguish normal aging from early-stage dementia. Attendees will gain knowledge about emerging therapeutic targets, lifestyle interventions, and multidisciplinary approaches to support healthy cognitive aging, ultimately contributing to improved prevention strategies and personalized care for older adults at risk of dementia.

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